Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor. Identification of pathways regulating B cell survival. Short title : Survival pathway induced by integrin in B cells
نویسندگان
چکیده
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 Department of Biostatistical Science, Harvard School of Public Health, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 Department of Medicine, Harvard Medical School, Boston, MA 02115 Department of Medicine, Indiana University School of Medicine, Indiana 46202 Biomedical Research Institute, Long Island Jewish Health System, New York 11030 The authors contributed equally to this work
منابع مشابه
Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival.
The physical interactions between B cells and stromal cells from the lymphoid tissue microenvironment are critical to the survival of normal and malignant B cells. They are principally mediated by integrins expressed on B cells and counterreceptors on stromal cells. Specifically, alpha4beta1 integrin engagement rescues B cells from physiological or drug-induced apoptosis. Therefore, in order to...
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تاریخ انتشار 2002